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The Pilot Series Preparative Liquid Chromatography System is a highly efficient, powerful, and modular preparative LC system. It improves the separation and purification processes for herbal medicines, synthetic chemical drugs, and biomacromolecules. The system supports gradient elution with up to five different mobile phases, simultaneous dual-wavelength online detection, and comes with software that complies with CFDA GxP and FDA 21 CFR Part 11 regulatory requirements. It features an audit trail function, allows easy method storage and recall, and enables fraction collection to be performed on the same platform. The system is suitable for applications ranging from laboratory research to industrial-scale production.

Feature:
Quickly purifies and prepares active compounds from both small molecules and biomacromolecules;
Modular design with built-in fraction collection for easy system expansion and upgrades;
Cam curve compensation reduces flow pulsation and keeps baseline noise low;
Multi-point flow calibration ensures accurate and reproducible flow across the full range;
Pump head auto-wash prevents buffer salt residue and crystallization;
Dual-wavelength detection (190–800 nm) for online analysis;
Easy lamp and flow cell replacement; deuterium and tungsten lamps switch automatically;
Supports optional detectors: UV-VIS, ELSD, RI, and more;
Optimized mixer path ensures efficient mixing with minimal dead volume;
Flow path materials available: 316L stainless steel, PEEK, titanium, and Hastelloy;
Automated fraction collector with multiple collection modes and tube size options;
Software compliant with CFDA GXP and FDA 21 CFR Part 11;
Database-based project management; all methods and data stored under each project;
Full audit trail and user permission management.
Technical Specifications:
Model | Pilot 50 |
HPLC Pump | High-precision 316L pump, optional: PEEK, titanium, Hastelloy |
Flow Range | 0.01~50 mL/min |
Flow Accuracy | ≤ ±0.5% |
Flow Reproducibility | ≤ 0.1% |
Pressure Range | 0~30 MPa |
Pulsation | ≤ 0.1 MPa |
Elution Mode | Isocratic, linear & step gradient; freely combinable and customizable |
Elution Mode | Isocratic, linear & step gradient; freely combinable and customizable |
Detector Lamp | Deuterium and tungsten lamps, with automatic light source switching |
Wavelength | 190~800 nm, dual-wavelength online detection |
Wavelength Accuracy | ±1 nm |
Wavelength Precision | ≤ 0.1 nm |
Absorbance Range | 0~3 AU |
Baseline Noise | ≤ ±0.5x10-5 AU |
Baseline Drift | ≤ 1.5x10-4 AU/h |
Collection Method | Automated fraction collector |
Collection Rack | 120-position 15 mL glass test tubes/42-position 50 mL centrifuge tubes |
Collection Mode | Manual, full, range, peak-based (time/threshold/slope) |
Injection Method | Manual injection valve (various loop sizes), solid loading, and pump loading |
Software | PC software workstation (Windows) via USB or RS232 Fully compliant with CFDA GxP and FDA 21 CFR Part 11 |
Power Supply | 100~240 VAC, 50/60 Hz |
Dimension | Pump: 370x240x152mm UV detector: 370x240x152mm Collector: 355x241x320mm |
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